Daf-16
DAF-16 is the sole ortholog of the FOXO family of transcription factors in the nematode Caenorhabditis elegans. It is responsible for activating genes involved in longevity, lipogenesis, heat shock survival and oxidative stress responses. It also protects C.elegans during food deprivation, causing it to transform into a hibernation - like state, known as a Dauer. DAF-16 is notable for being the primary transcription factor required for the profound lifespan extension observed upon mutation of the insulin-like receptor DAF-2. The gene has played a large role in research into longevity and the insulin signalling pathway as it is located in C. elegans, a successful ageing model organism.
Link from a Wikipage to another Wikipage
primaryTopic
Daf-16
DAF-16 is the sole ortholog of the FOXO family of transcription factors in the nematode Caenorhabditis elegans. It is responsible for activating genes involved in longevity, lipogenesis, heat shock survival and oxidative stress responses. It also protects C.elegans during food deprivation, causing it to transform into a hibernation - like state, known as a Dauer. DAF-16 is notable for being the primary transcription factor required for the profound lifespan extension observed upon mutation of the insulin-like receptor DAF-2. The gene has played a large role in research into longevity and the insulin signalling pathway as it is located in C. elegans, a successful ageing model organism.
has abstract
DAF-16 is the sole ortholog of ...... cessful ageing model organism.
@en
Wikipage page ID
29,395,245
page length (characters) of wiki page
Wikipage revision ID
1,019,641,499
Link from a Wikipage to another Wikipage
wikiPageUsesTemplate
hypernym
comment
DAF-16 is the sole ortholog of ...... cessful ageing model organism.
@en
label
Daf-16
@en