Dinalbuphine sebacate
Dinalbuphine sebacate (DNS), also known as nalbuphine sebacate or as sebacoyl dinalbuphine ester (SDE) and sold under the brand name Naldebain, is a non-controlled opioid analgesic which is used as a 7-day long-acting injection in the treatment of moderate to severe postoperative pain. It was invented by professor Oliver Yoa-Pu Hu (National Defense Medical Center) and codeveloped with Lumosa Therapeutics. Naldebain received market approvals from Taiwan FDA in March 2017 and Health Sciences Authority of Singapore in December 2020. Development is ongoing in the United States, China, Korea, Thailand, Malaysia. Philippines, and Brunei. The compound is a diester of nalbuphine (Nubain) joined via a sebacic acid linker, and acts as a long-lasting prodrug of nalbuphine via slow hydrolysis. It was
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DNS (disambiguation)DinalbuphineLT-1001LT1001LT 1001NalbuphineNalbuphine sebacateNaldebainSDESDNSebacoyl dinalbuphineSebacoyl dinalbuphine esterSebacoyl nalbuphineSebacoyl nalbuphine diesterSebacoyl nalbuphine esterSebacoyldinalbuphineSebacoyldinalbuphine esterSebacoylnalbuphineSebacoylnalbuphine diesterSebacoylnalbuphine ester
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Dinalbuphine sebacate
Dinalbuphine sebacate (DNS), also known as nalbuphine sebacate or as sebacoyl dinalbuphine ester (SDE) and sold under the brand name Naldebain, is a non-controlled opioid analgesic which is used as a 7-day long-acting injection in the treatment of moderate to severe postoperative pain. It was invented by professor Oliver Yoa-Pu Hu (National Defense Medical Center) and codeveloped with Lumosa Therapeutics. Naldebain received market approvals from Taiwan FDA in March 2017 and Health Sciences Authority of Singapore in December 2020. Development is ongoing in the United States, China, Korea, Thailand, Malaysia. Philippines, and Brunei. The compound is a diester of nalbuphine (Nubain) joined via a sebacic acid linker, and acts as a long-lasting prodrug of nalbuphine via slow hydrolysis. It was
has abstract
Dinalbuphine sebacate (DNS), a ...... nist of the κ-opioid receptor.
@en
CAS number
311768-81-7
ChEMBL
class
FDA UNII code
464OXX39Y6
PubChem
Wikipage page ID
57,709,360
page length (characters) of wiki page
Wikipage revision ID
1,019,926,338
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bioavailability
• : 85.4%
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CAS number
ChEMBL
ChemSpiderID
elimination half-life
IUPAC name
Bis[-3--4a,7-dihydroxy-1,2,4,5 ...... soquinoline-9-yl] decanedioate
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metabolism
metabolites
PubChem
routes of administration
SMILES
C1CCCN2CC[C@]34[C@@H]5[C@H]O
@en
StdInChIKey
ALOIOAGKUOQNID-ITCIXCFHSA-N
@en
synonyms
DNS; Nalbuphine sebacate; Seba ...... nalbuphine ester; SDE; LT-1001
@en
wikiPageUsesTemplate
subject
comment
Dinalbuphine sebacate (DNS), a ...... e via slow hydrolysis. It was
@en
label
Dinalbuphine sebacate
@en