Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubules. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-disco
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Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubules. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-disco
has abstract
(+)-Discodermolide is a polyke ...... m large-scale total synthesis.
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(+)-Diskodermolida adalah prod ...... asetat dengan 13 stereopusat.
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A (+)-discodermolida é um poli ...... cetato, com 13 estereocentros.
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La (+)-discodermolida es un po ...... cetato, con 13 estereocentros.
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Le discodermolide est un polyc ...... des cliniques et précliniques.
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IUPAC name
(3Z,5S,6S,7S,8R,9S,11Z,13S,14S ...... 3,11,16-tetraen-6-yl carbamate
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1,023,374,773
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ImageName
-Discodermolide
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name
Discodermolide
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477,388,975
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(+)-Discodermolide is a polyke ...... e total synthesis of (+)-disco
@en
(+)-Diskodermolida adalah prod ...... asetat dengan 13 stereopusat.
@in
A (+)-discodermolida é um poli ...... cetato, com 13 estereocentros.
@pt
La (+)-discodermolida es un po ...... cetato, con 13 estereocentros.
@es
Le discodermolide est un polyc ...... des cliniques et précliniques.
@fr
label
Discodermolida
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Discodermolida
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Discodermolide
@en
Discodermolide
@fr
Diskodermolida
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isPrimaryTopicOf
name
Discodermolide
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