Discovery and development of HIV-protease inhibitors
Many major physiological processes depend on regulation of proteolytic enzyme activity and there can be dramatic consequences when equilibrium between an enzyme and its substrates is disturbed. In this prospective, the discovery of small-molecule ligands, like protease inhibitors, that can modulate catalytic activities has an enormous therapeutic effect. Hence, inhibition of the HIV protease is one of the most important approaches for the therapeutic intervention in HIV infection and their development is regarded as major success of structure-based drug design. They are highly effective against HIV and have, since the 1990s, been a key component of anti-retroviral therapies for HIV/AIDS.
AtazanavirDiscovery and Development of HIV Protease InhibitorsDiscovery and development of HIV protease inhibitorsDiscovery and development of beta-blockersDiscovery and development of non-nucleoside reverse-transcriptase inhibitorsDiscovery and development of nucleoside and nucleotide reverse-transcriptase inhibitorsDrug designHIVHIV-1 proteaseHIV/AIDS researchManagement of HIV/AIDS
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Discovery and development of HIV-protease inhibitors
Many major physiological processes depend on regulation of proteolytic enzyme activity and there can be dramatic consequences when equilibrium between an enzyme and its substrates is disturbed. In this prospective, the discovery of small-molecule ligands, like protease inhibitors, that can modulate catalytic activities has an enormous therapeutic effect. Hence, inhibition of the HIV protease is one of the most important approaches for the therapeutic intervention in HIV infection and their development is regarded as major success of structure-based drug design. They are highly effective against HIV and have, since the 1990s, been a key component of anti-retroviral therapies for HIV/AIDS.
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Many major physiological proce ...... oviral therapies for HIV/AIDS.
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Many major physiological proce ...... oviral therapies for HIV/AIDS.
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Discovery and development of HIV-protease inhibitors
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HIV-단백질분해효소 억제제의 발견과 발전
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