Domenico Reina (July 14, 1796 – July 29, 1843) was a Swiss bel canto tenor, notable for creating roles in the operas of Vincenzo Bellini, Gaetano Donizetti, Saverio Mercadante, and other Italian composers. He was born in Lugano, studied in Milan and made his operatic debut in 1820. He joined John Ebers's company at the King's Theatre, Haymarket and in 1823 sang in the first London performances of Gioachino Rossini's operas Ricciardo e Zoraide, La donna del lago and Matilde di Shabran. Other composers in whose operas Reina sang at the first performances were: Domenico Reina died in Milan in 1843.