The Ernest Guenther Award in the Chemistry of Natural Products is an American Chemical Society (ACS) award in the field of the chemistry of natural products. The purpose of the award is to recognize and encourage outstanding achievements in the analysis, structure elucidation, and chemical synthesis of natural products, with special consideration given to the independence of thought and originality. The award is granted regardless of race, gender, age, religion, ethnicity, nationality, sexual orientation, gender expression, gender identity, presence of disabilities, and educational background. The award consists of $6,000, a medallion, and a certificate. The medallion is presented during an award address.