Esaxerenone
Esaxerenone (INN) (brand name Minnebro; developmental code names CS-3150, XL-550) is a nonsteroidal antimineralocorticoid which was discovered by Exelixis and developed by Daiichi Sankyo Company and is approved in Japan for the treatment of hypertension. It acts as a highly selective silent antagonist of the mineralocorticoid receptor (MR), the receptor for aldosterone, with greater than 1,000-fold selectivity for this receptor over other steroid hormone receptors, and 4-fold and 76-fold higher affinity for the MR relative to the existing antimineralocorticoids spironolactone and eplerenone. As of January 2019, esaxerenone is in phase III clinical trials for diabetic nephropathies.
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Esaxerenone
Esaxerenone (INN) (brand name Minnebro; developmental code names CS-3150, XL-550) is a nonsteroidal antimineralocorticoid which was discovered by Exelixis and developed by Daiichi Sankyo Company and is approved in Japan for the treatment of hypertension. It acts as a highly selective silent antagonist of the mineralocorticoid receptor (MR), the receptor for aldosterone, with greater than 1,000-fold selectivity for this receptor over other steroid hormone receptors, and 4-fold and 76-fold higher affinity for the MR relative to the existing antimineralocorticoids spironolactone and eplerenone. As of January 2019, esaxerenone is in phase III clinical trials for diabetic nephropathies.
has abstract
Esaxerenone (INN) (brand name ...... ls for diabetic nephropathies.
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alternative name
Minnebro
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CAS number
1632006-28-0
ChEMBL
FDA UNII code
N62TGJ04A1
KEGG
PubChem
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Wikipage page ID
54,193,778
page length (characters) of wiki page
Wikipage revision ID
997,139,639
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CAS number
ChEMBL
ChemSpiderID
28,666,733
IUPAC name
KEGG
D10892
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PubChem
25,052,023
routes of administration
SMILES
CC1=CC3=CC=CC=C3CF
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StdInChIKey
NOSNHVJANRODGR-UHFFFAOYSA-N
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synonyms
CS-3150; XL-550
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tradename
Minnebro
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UNII
N62TGJ04A1
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wikiPageUsesTemplate
subject
comment
Esaxerenone (INN) (brand name ...... ls for diabetic nephropathies.
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label
Esaxerenone
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