GABAA receptor positive allosteric modulator
In pharmacology, GABAA receptor positive allosteric modulators are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system. Unlike GABAA receptor agonists, GABAA PAMs do not bind at the same active site as the γ-Aminobutyric acid (GABA) neurotransmitter molecule: they affect the receptor by binding at a different site on the protein. This is called allosteric modulation.
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GABAA receptor positive allosteric modulator
In pharmacology, GABAA receptor positive allosteric modulators are positive allosteric modulator (PAM) molecules that increase the activity of the GABAA receptor protein in the vertebrate central nervous system. Unlike GABAA receptor agonists, GABAA PAMs do not bind at the same active site as the γ-Aminobutyric acid (GABA) neurotransmitter molecule: they affect the receptor by binding at a different site on the protein. This is called allosteric modulation.
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In pharmacology, GABAA recepto ...... en) and the barbiturate drugs.
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Fig 1. Chemical structure of gamma-Aminobutyric acid or GABA
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Fig 2. Schematic diagram of a ...... te at the α1 and γ2 interface.
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Fig 5. Original synthesis of Barbituric acid
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Fig 6. Current synthesis of barbituric acid
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In pharmacology, GABAA recepto ...... called allosteric modulation.
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GABAA receptor positive allosteric modulator
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