In statistics, a generalized p-value is an extended version of the classical p-value, which except in a limited number of applications, provides only approximate solutions. Conventional statistical methods do not provide exact solutions to many statistical problems, such as those arising in mixed models and MANOVA, especially when the problem involves a number of nuisance parameters. As a result, practitioners often resort to approximate statistical methods or asymptotic statistical methods that are valid only when the sample size is large. With small samples, such methods often have poor performance. Use of approximate and asymptotic methods may lead to misleading conclusions or may fail to detect truly significant results from experiments.