Giovanni Battista de' Rossi (22 February 1698 – 23 May 1764) was an Italian Roman Catholic priest. He served as the canon of Santa Maria in Cosmedin after his cousin, who was a priest serving there, died. He was a popular confessor despite his initial fears that his epileptic seizures could manifest in the Confessional. Rossi opened a hospice for homeless women not long after his ordination, and he became known for his work with prisoners and ill people, to whom he dedicated his entire ecclesial mission.