Girolamo Prigione (12 October 1921 – 27 May 2016) was an Italian prelate of the Roman Catholic Church who worked in the diplomatic service of the Holy See from 1951 to 1997. He became an archbishop in 1968 and from then until retirement held positions at the rank of apostolic delegate or apostolic nuncio in several countries, including almost twenty years in Mexico where he became a controversial figure.