Gla domain
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla). Proteins with this domain are known informally as Gla proteins. The Gla residues are responsible for the high-affinity binding of calcium ions. In all cases in which their function was known, the presence of the Gla residues in these proteins turned out to be essential for functional activity.
Wikipage disambiguates
Wikipage redirect
C4b-binding proteinDiscovery and development of direct Xa inhibitorsEGF-like domain1,2-dimethoxyethaanFasciclin domainGAS6GLAGLA domainGamma-glutamyl carboxylaseGla proteinITIH2Kringle domainMatrix Gla proteinNAD(P)H dehydrogenase (quinone 1)OsteocalcinPeriostinProline-rich 121,2-dimethoxyethaanProtein SProtein ZProthrombinaseTenase1,2-dimethoxyethaan1,2-dimethoxyethaan1,2-dimethoxyethaanVitamin KVitamin K-dependent proteinVitamin K2
Link from a Wikipage to another Wikipage
primaryTopic
Gla domain
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form γ-carboxyglutamate (Gla). Proteins with this domain are known informally as Gla proteins. The Gla residues are responsible for the high-affinity binding of calcium ions. In all cases in which their function was known, the presence of the Gla residues in these proteins turned out to be essential for functional activity.
has abstract
Vitamin K-dependent carboxylat ...... ntial for functional activity.
@en
Wikipage page ID
14,091,970
page length (characters) of wiki page
Wikipage revision ID
993,479,083
Link from a Wikipage to another Wikipage
caption
Anchoring of Coagulation factor VIIa to the membrane through its GLA domain
@en
InterPro
IPR000294
@en
Membranome superfamily
name
GLA Domain
@en
OPM family
OPM protein
Pfam
PF00594
@en
PROSITE
PDOC00011
@en
symbol
Gla
@en
wikiPageUsesTemplate
hypernym
comment
Vitamin K-dependent carboxylat ...... ntial for functional activity.
@en
label
Gla domain
@en