Hatice Açıkalın (1909 – May 13, 2003) was a Turkish female physician specialized in cardiology. She was born in 1909. She was the sister of , an ambassador and one of the close associates of Mustafa Kemal Atatürk (1881-1938). She worked with hematology Jean Pierre Soulier (1915–2003) at the University of Paris, and achieved her specialization in Internal medicine shortly before World War II. During the 1950s and 1960, she served as an internist at in Istanbul. From 1974 until her retirement, she was the head of Internal medicine Clinic at .