The ultraviolet radiation in sunlight has both positive and negative health effects, as it is required for the synthesis of vitamin D3 and is a mutagen. A dietary supplement can supply vitamin D without this mutagenic effect. Vitamin D has been suggested as having a wide range of positive health effects, which include strengthening bones and possibly inhibiting the growth of some cancers. UV exposure also has positive effects for endorphin levels, and possibly for protection against multiple sclerosis. Visible sunlight to the eyes gives health benefits through its association with the timing of melatonin synthesis, maintenance of normal and robust circadian rhythms, and reduced risk of seasonal affective disorder.