Hereditary diffuse gastric cancer
Hereditary diffuse gastric cancer (HDGC) is an inherited genetic syndrome most often caused by an inactivating mutation in the E-cadherin gene (CDH1) located on chromosome 16. Individuals who inherit an inactive copy of the CDH1 gene are at significantly elevated risk for developing stomach cancer. For this reason, individuals with these mutations will often elect to under go prophylactic gastrectomy, or a complete removal of the stomach to prevent this cancer. Mutations in CDH1 are also associated with high risk of lobular breast cancers, and may be associated with a mildly elevated risk of colon cancer.
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Hereditary diffuse gastric cancer
Hereditary diffuse gastric cancer (HDGC) is an inherited genetic syndrome most often caused by an inactivating mutation in the E-cadherin gene (CDH1) located on chromosome 16. Individuals who inherit an inactive copy of the CDH1 gene are at significantly elevated risk for developing stomach cancer. For this reason, individuals with these mutations will often elect to under go prophylactic gastrectomy, or a complete removal of the stomach to prevent this cancer. Mutations in CDH1 are also associated with high risk of lobular breast cancers, and may be associated with a mildly elevated risk of colon cancer.
has abstract
Hereditary diffuse gastric can ...... d as young as 14 years of age.
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Le cancer de l'estomac hérédit ...... % de cancer lobulaire du sein.
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complications
Lobularbreast cancer
medical cause
synonym
treatment
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43,187,879
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1,021,320,220
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Diagram demonstrating the end ...... nected to the small intestine.
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causes
Mutation of the E-cadherin gene
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complications
frequency
name
Hereditary diffuse gastric cancer
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onset
1.1991888E9
risks
synonym
HDGC
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treatment
Total gastrectomy
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wikiPageUsesTemplate
subject
hypernym
comment
Hereditary diffuse gastric can ...... elevated risk of colon cancer.
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Le cancer de l'estomac hérédit ...... t 25 %) survient avant 40 ans.
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label
Cancer de l'estomac héréditaire
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Hereditary diffuse gastric cancer
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isPrimaryTopicOf
name
Hereditary diffuse gastric cancer
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