Danielle "Hopi" Elizabeth Hoekstra (born 1972) is an evolutionary biologist working at Harvard University in Cambridge, Massachusetts. Her lab uses natural populations of rodents to study the genetic basis of adaptation. She is the Alexander Agassiz Professor of Zoology in the Department of Organismic and Evolutionary Biology and the Department of Molecular and Cellular Biology at Harvard University. She is also the Curator of Mammals at the Museum of Comparative Zoology and a Harvard College Professor. In 2014, Hoekstra became a Howard Hughes Medical Institute Investigator. In 2016, she was elected to the National Academy of Sciences, and in 2017, she was elected to the American Academy of Arts and Sciences.