Hughes–Drever experiments (also clock comparison-, clock anisotropy-, mass isotropy-, or energy isotropy experiments) are spectroscopic tests of the isotropy of mass and space. Although originally conceived of as a test of Mach's principle, it is now understood to be an important test of Lorentz invariance. As in Michelson–Morley experiments, the existence of a preferred frame of reference or other deviations from Lorentz invariance can be tested, which also affects the validity of the equivalence principle. Thus these experiments concern fundamental aspects of both special and general relativity. Unlike Michelson–Morley type experiments, Hughes–Drever experiments test the isotropy of the interactions of matter itself, that is, of protons, neutrons, and electrons. The accuracy achieved mak