The Isaac Block House is a historic house at 404 East Hamilton Street in Wynne, Arkansas. It is a 1+1⁄2-story wood-frame structure, locally notable for its fine Queen Anne styling. On the exterior this is evident in the wraparound porch, the use of fish-scale wood shingles, a projecting gable with carved decoration, and projecting bays that are similarly decorated. The house was built in Wittsburg in about 1885 by Isaac Block, a merchant son of German Jewish immigrants. After the railroad bypassed Wittsburg, Block decided to move the house to Wynne, a feat accomplished in the early 1900s by cutting the house into sections and hauling them on oversized wagons to the present location.