Isaac Staples' Sawmill is a historic industrial property in Stillwater, Minnesota, United States, consisting of an 1850 stone powerhouse and a 1900 metal-clad factory. The property was listed on the National Register of Historic Places as St. Croix Lumber Mills—Stillwater Manufacturing Company in 1982 for its local significance in the theme of industry. It was nominated because the powerhouse is the only surviving industrial building associated with Isaac Staples (1816–1898), a major figure in Minnesota's early commercial development. The property now operates as a shopping mall with upper level apartments.