Isunigu (also called Seneca, Esseneca, and Sinica) was a Cherokee town on the Keowee River. It was on the west side of the Keowee River, near the mouth of Coneross Creek, in today's Oconee County, South Carolina. Present-day Clemson and Seneca, South Carolina later developed hear here. Andrew Pickens developed his "Hopewell" plantation on the east side of the Keowee River. Following the American Revolution and conflict between the Cherokee and European Americans, this was where the 1785 Treaty of Hopewell was signed by both parties.