The Jesse Whitesell House and Farm is a historic property in Fulton County, Kentucky, and Obion County, Tennessee. The house, which is located in Kentucky, was listed on the National Register of Historic Places in 1977. The associated farm was added to the National Register in 2009 as a historic district. The historic district includes about 215 acres (87 ha) of land that spans the state line, five contributing buildings and five other contributing sites. The house was built in 1871 for Jesse Whitesell, in the style of an Italianate villa.