The John and Marie (Palen) Schrup Farmstead Historic District is a nationally recognized historic district in Dubuque County, Iowa, United States. It was listed on the National Register of Historic Places in 2009. At the time of its nomination it consisted of four resources, which included three contributing buildings and one non-contributing building. The three buildings include a stone house (c. 1854), barn (c. 1860), and well-house (c. 1860). The buildings are typical of those constructed by immigrant families from Luxembourg that settled in Dubuque and nearby Jackson counties. The front part of the house is the oldest structure here and was built when Martin Burkhart owned the property. He sold the farmstead to Casper Burkhart the following year, who then sold it to John and Marie Schr