Jorge de Cárdenas y Manrique de Lara (April 23, 1584 – October 30, 1644), 4th Duke of Maqueda and 6th Duke of Nájera, was a Spanish noble, military and statesman, born in Elche. He was the son of Bernardino de Cárdenas y Portugal, 3rd Duke of Maqueda, 2nd Marquis of Elche, and of Luisa Manrique de Lara, 5th Duchess of Nájera. He married in 1633 with Isabel de la Cueva y Enriquez de Cabrera, daughter of Francisco Fernández de la Cueva, 7th Duke of Alburquerque, but they had no children.He was succeeded by his younger brother Jaime Manuel de Cárdenas y Manrique de Lara.