The Karpeles Manuscript Library Museum is a museum in Jacksonville, Florida, one of fifteen Karpeles Manuscript Library Museums in the United States, all housed in repurposed old buildings. Other locations of Karpeles Museums include Buffalo, NY; Charleston, SC; Duluth, MI; Newburgh, NY; Santa Barbara, CA; Tacoma, WA; Shreveport, LA; Fort Wayne, IN; Alvin, TX; Rock Island, IL; St. Louis, MO; Gloversville, NY; Pittsburgh, PA; and Great Falls, MT. Karpeles Manuscript Library Museums display manuscripts and documents from the private collection of David and Marsha Karpeles, the world's largest such collection, as well as art exhibits.