L-368,899
L-368,899 is a drug used in scientific research which acts as a selective antagonist of the oxytocin receptor, with good selectivity over the related vasopressin receptors. Unlike related drugs such as the peripherally selective L-371,257, the oral bioavailabity is high and the brain penetration of L-368,899 is rapid, with selective accumulation in areas of the limbic system. This makes it a useful tool for investigating the centrally mediated roles of oxytocin, such as in social behaviour and pair bonding, and studies in primates have shown L-368,899 to reduce a number of behaviours such as food sharing, sexual activity and caring for infants, demonstrating the importance of oxytocinergic signalling in mediating these important social behaviours.
Wikipage redirect
Link from a Wikipage to another Wikipage
primaryTopic
L-368,899
L-368,899 is a drug used in scientific research which acts as a selective antagonist of the oxytocin receptor, with good selectivity over the related vasopressin receptors. Unlike related drugs such as the peripherally selective L-371,257, the oral bioavailabity is high and the brain penetration of L-368,899 is rapid, with selective accumulation in areas of the limbic system. This makes it a useful tool for investigating the centrally mediated roles of oxytocin, such as in social behaviour and pair bonding, and studies in primates have shown L-368,899 to reduce a number of behaviours such as food sharing, sexual activity and caring for infants, demonstrating the importance of oxytocinergic signalling in mediating these important social behaviours.
has abstract
L-368,899 is a drug used in sc ...... e important social behaviours.
@en
CAS number
148927-60-0
FDA UNII code
ER33G946JT
PubChem
Wikipage page ID
31,475,159
page length (characters) of wiki page
Wikipage revision ID
1,015,356,717
Link from a Wikipage to another Wikipage
ATC prefix
None
@en
CAS number
IUPAC name
IUPHAR ligand
PubChem
SMILES
CC1[C@@]2CC[C@@H]1C[C@@H]2NC=O
@en
UNII
ER33G946JT
@en
verifiedrevid
451,607,732
Watchedfields
changed
@en
wikiPageUsesTemplate
hypernym
comment
L-368,899 is a drug used in sc ...... e important social behaviours.
@en
label
L-368,899
@en