Luke Garnons (died 12 February 1615) was an English merchant and politician who sat in the House of Commons variously between 1584 and 1601. Garnons was a younger son of John Garnons of Herefordshire and became a draper in Gloucester, acquiring a number of properties in the town. As part of his civic interests in Gloucester, he was deeply involved in maritime trade from the city. In 1566, he became an alderman of the City. He was twice sheriff (for 1565 and 1569) and three times mayor (for 1570-71, 1586–87, 1600–01) and was described as a 'sage and prudent ruler'.