Isaias Guadalupe "Lupe" Aquino (born January 23, 1963 in Chihuahua, Chihuahua, Mexico) is a Mexican former professional boxer who competed from 1981 to 1999. Aquino, known as "Lupe", turned pro in 1981 and won the WBC light middleweight title in 1987 with a decision over Duane Thomas. He lost the title in his first defense via a close decision to Gianfranco Rosi. In 1988 Aquino took on John David Jackson for the inaugural WBO light middleweight title. In the fight, Aquino was put down in 1st and retired after the 7th round. Aquino continued to fight until 1999 but never again challenged for a major title. His biggest fight in that time period was probably the one he had against Bernard Hopkins, which he lost.