MK-2048
MK-2048 is the Merck & Co. designation for a molecule in its pre-clinical drug discovery that is an integrase inhibitor-class of agent intended to be used against HIV infection. It is a second generation integrase design thought to be superior to the first available integrase inhibitor, raltegravir, in that "MK-2048 has a dissociation half-life of 32 hours on wild-type integrase—more than four times that of raltegravir", and its dissociation half-life against the important HIV integrase mutant N155H was on the same order of magnitude as that of raltegravir against wild-type virus, leading the Merck presenter to suggest the possibility of "reduced susceptibility to resistance mutations" for the second generation drug. MK-2048 is being investigated for use as part of a pre-exposure prophylax
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MK-2048
MK-2048 is the Merck & Co. designation for a molecule in its pre-clinical drug discovery that is an integrase inhibitor-class of agent intended to be used against HIV infection. It is a second generation integrase design thought to be superior to the first available integrase inhibitor, raltegravir, in that "MK-2048 has a dissociation half-life of 32 hours on wild-type integrase—more than four times that of raltegravir", and its dissociation half-life against the important HIV integrase mutant N155H was on the same order of magnitude as that of raltegravir against wild-type virus, leading the Merck presenter to suggest the possibility of "reduced susceptibility to resistance mutations" for the second generation drug. MK-2048 is being investigated for use as part of a pre-exposure prophylax
has abstract
MK-2048 est une molécule de la ...... égrase de nouvelle génération.
@fr
MK-2048 is the Merck & Co. des ...... be ready for clinical trials".
@en
MK-2048系第二代整合酶抑制剂,是抗病毒药品,用于对抗H ...... EP)的实用性正在研究当中。 MK-2048由默克藥廠开发。
@zh
CAS number
869901-69-9
ChEMBL
FDA UNII code
LJ8U884TM5
PubChem
Wikipage page ID
25,019,159
page length (characters) of wiki page
Wikipage revision ID
1,014,907,671
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ATC prefix
none
@en
caption
MK-2048
@en
CAS number
ChEMBL
ChemSpiderID
25,058,456
IUPAC name
legal US
Investigational New Drug
@en
PubChem
11,554,427
SMILES
CCN1CCC
@en
StdInChIKey
IOYLKNABOQYKKY-JTQLQIEISA-N
@en
UNII
LJ8U884TM5
@en
wikiPageUsesTemplate
hypernym
comment
MK-2048 est une molécule de la ...... égrase de nouvelle génération.
@fr
MK-2048 is the Merck & Co. des ...... rt of a pre-exposure prophylax
@en
MK-2048系第二代整合酶抑制剂,是抗病毒药品,用于对抗H ...... EP)的实用性正在研究当中。 MK-2048由默克藥廠开发。
@zh
label
MK-2048
@en
MK-2048
@fr
MK-2048
@zh