Madeleine M. Joullié (born March 29, 1927) is a French-born American organic chemist. She was the first woman to join the University of Pennsylvania chemistry faculty as well as the first female organic chemist to be appointed to a tenure track position in a major American university. She was one of the first affirmative action officers at the University of Pennsylvania. She has a distinguished record as a teacher of both undergraduate and graduate-level organic chemistry, and as a mentor of students.