Margarita Bertheau Odio (born in San José, Costa Rica on 13 May 1913; died in Escazú (canton) on 21 November 1975) was a Costa Rican painter and cultural promoter. The Costa Rican Art Museum states she is said to be known for "landscapes, portraits, watercolor figures, and her geometric, surrealistic and abstract work." She has been called the first female Watercolor painting artist of her country. She had independent views and was contemporary with the first wave of Costa Rican artists that included Dinora Bolandi, Lola Fernandez and . These four are said to have taught fine art at the University of Costa Rica and to have created the second generation of Costa Rican women artists.