Maria, Lady Walpole (née Skerritt, Skerrett, or Skerret; 1702 – 4 June 1738) was the second wife of British politician and Prime Minister Robert Walpole from before 3 March 1738 until her death in childbirth (miscarriage) three months later. She was buried on the Walpole estate at Houghton Hall in Norfolk, England. Lady Walpole was the only known daughter of Thomas Skerret, a wealthy London merchant. On her marriage to Walpole in 1738 she paid a dowry of £30,000.