Maria Spiropulu (/ˌspɪrəˈpuːluː/; Greek: Μαρία Σπυροπούλου) is the Shang-Yi Ch’en Professor of Physics at the California Institute of Technology. She received her PhD in physics from Harvard and was Enrico Fermi Fellow at the University of Chicago before moving to CERN as a research physicist.She worked at the Tevatron’s collider experiments and at the CERN's Large Hadron Collider with leading roles on detector and trigger R&D and operations and breakthroughs in the searches for dark matter and other new physics including the discovery of the Higgs boson. In 2014, she initiated a program to explore and apply quantum computation and artificial intelligence tools towards accelerating discovery in high energy particle physics and other domain sciences.