Mariano Agate (19 May 1939 in Mazara del Vallo – 3 April 2013 in Mazara del Vallo) was a member of the Sicilian Mafia. He was the boss of Mazara del Vallo Mafia family since the 1970s when he replaced the old boss . He also was the boss of the mandamento of Mazara, including the Mafia families of Marsala, Salemi and Vita. Agate was a member of "Iside", one of the most powerful local Masonic lodges. In the 1990s, members of his clan worked together with the 'Ndrangheta clan headed by Giuseppe Morabito from Africo to import hashish from Morocco and cocaine from Latin America.