Melphalan flufenamide
Melphalan flufenamide, sold under the brand name Pepaxto, is an anticancer medication used to treat multiple myeloma. The most common adverse reactions include fatigue, nausea, diarrhea, pyrexia and respiratory tract infection. Melphalan flufenamide is a peptidase enhanced cytotoxic (PEnC) that exerts a targeted delivery of melphalan in cells with high expression of aminopeptidases, such as aminopeptidase N, which has been described as over-expressed in human malignancies. Aminopeptidase N plays a functional role in malignant angiogenesis.
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Melphalan flufenamide
Melphalan flufenamide, sold under the brand name Pepaxto, is an anticancer medication used to treat multiple myeloma. The most common adverse reactions include fatigue, nausea, diarrhea, pyrexia and respiratory tract infection. Melphalan flufenamide is a peptidase enhanced cytotoxic (PEnC) that exerts a targeted delivery of melphalan in cells with high expression of aminopeptidases, such as aminopeptidase N, which has been described as over-expressed in human malignancies. Aminopeptidase N plays a functional role in malignant angiogenesis.
has abstract
Melphalan flufenamide, sold un ...... nited States in February 2021.
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alternative name
Pepaxto
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CAS number
380449-51-4
ChEMBL
DrugBank
FDA UNII code
F70C5K4786
PubChem
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Wikipage page ID
49,620,393
page length (characters) of wiki page
Wikipage revision ID
1,015,294,468
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ATC prefix
None
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CAS number
ChEMBL
ChemSpiderID
DailyMedID
Melphalan_flufenamide
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DrugBank
DB16627
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elimination half-life
IUPAC name
Ethyl -2-(2S)-2-amino-3-[4-[bi ...... ]-3-(4-fluorophenyl)propanoate
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legal US
Rx-only
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metabolism
Aminopeptidase hydrolysis, Spontaneous hydrolyisis on N-mustard
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PubChem
SMILES
CCOC[C@H]NC[C@H]N
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StdInChIKey
YQZNKYXGZSVEHI-VXKWHMMOSA-N
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synonyms
Melflufen, 4-[Bis-amino]-(L)-phenylalanine-4-fluoro-(L)-phenylalanine ethyl ester, J1
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tradename
Pepaxto
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UNII
F70C5K4786
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wikiPageUsesTemplate
comment
Melphalan flufenamide, sold un ...... ole in malignant angiogenesis.
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label
Melphalan flufenamide
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