Millwood Commercial Historic District is a national historic district located at Millwood, Clarke County, Virginia. Millwood developed after the American Revolutionary War around the Burwell-Morgan Mill (1782-1785; listed in the NRHP since 1969), along Spout Run and one of the largest in the area. It is near several roads important in the colonial era, including Route 17 and Route 340. Col. Nathaniel Burwell (1750-1814), who owned over 5,000 acres in the agriculturally productive area constructed it with General Daniel Morgan (1736-1802) as his business partner. The mill had become derelict by the 1940s, when it was acquired by the Clarke County Historical Association, which restored it and operates it as a living history museum.