The Mississinewa Valley Conference was an IHSAA-sanctioned conference based in East Central Indiana that lasted between 1952 and 1977. The conference started out as a conference for larger rural schools as a way to provide a higher level of competition than their respective County Conferences typically provided. The conference was stable for its first decade, but consolidation and more regionally based conferences with schools of similar sizes had schools defecting the MVC. The conference ended in 1977, with three schools forming the Classic Athletic Conference, and one team each joining the Mid-Eastern and Mid-Indiana conferences.