Mississippi Highway 41 (MS 41) is a state highway in northeastern Mississippi. The route starts at U.S. Route 45 (US 45) and US 278 north of Wren and travels westwards. It then intersects US 45 Alt. east of Okolona. The road enters Okolona, and intersects MS 32 and MS 245. MS 41 then turns northwest and travels toward Pontotoc. Once inside the city, the route turns north at MS 15 and travels through downtown Pontotoc. MS 41 ends at its intersection with MS 9 and . The route that became MS 41 was first used as an Indian trail. The route was designated by 1932 from Amory to Pontotoc, and it was truncated from Amory to US 45 by 1955. The entirety of MS 41 was paved by 1958.