Muhammad Riaz Khan (Urdu/Punjabi: محمد ریاض خان) was a Pakistan Army general who was the 6th Director-General of the Inter-Services Intelligence (ISI), serving from 1977 to 1979. Prior to that, he served at the General Headquarters as Adjutant-General of the Pakistan Army. Riaz died in 1979 from cardiac arrest. His post was seceded by Akhtar Abdur Rahman. His son-in-law, Shahid Khaqan Abbasi, became a prominent politician and was appointed as the Prime Minister of Pakistan in 2017.