New York State Route 280 (NY 280) is an 11.59-mile (18.65 km) long north–south state highway in rural Cattaraugus County, New York, in the United States. The southern terminus of the route is at the Pennsylvania state line in South Valley, where it becomes Pennsylvania Route 346 (PA 346). The northern terminus is at exit 18 on the Southern Tier Expressway (Interstate 86 or I-86 and NY 17) in Coldspring, west of Salamanca. NY 280 follows both the eastern edge of the Allegheny Reservoir and the western boundary of Allegany State Park for its entire length.