New York State Route 48 (NY 48) is a 28.20-mile (45.38 km) north–south state highway in Central New York in the United States. The southern terminus of the route is located at Interstate 690 (I-690) exit 3 near the interchange between I-690 and the New York State Thruway (I-90) in Van Buren, northwest of Syracuse. The northern terminus is located at an intersection with NY 104 in Oswego. In between, NY 48 passes through the riverside communities of Baldwinsville and Fulton and runs alongside both the Seneca River and Oswego River. For most of its route, NY 48 serves as an alternate route of NY 481. The routes share similar alignments along the Oswego River from the Syracuse area to Oswego, with NY 481 following the eastern riverbank between the two locations.