Nicolaou Taxol total synthesis
The Nicolaou Taxol total synthesis, published by K. C. Nicolaou and his group in 1994 concerns the total synthesis of Taxol. Taxol is an important drug in the treatment of cancer but also expensive because the compound is harvested from a scarce resource, namely the pacific yew. This synthetic route to taxol is one of several; other groups have presented their own solutions, notably the group of Holton with a linear synthesis starting from borneol, the Samuel Danishefsky group starting from the Wieland-Miescher ketone and the Wender group from pinene.
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AcetonideDanishefsky Taxol total synthesisDiels–Alder reactionHolton Taxol total synthesisK. C. NicolaouKuwajima Taxol total synthesisMcMurry reactionMucic acidMukaiyama Taxol total synthesisNicolaou taxol total synthesisOrganic synthesisPaclitaxelPaclitaxel total synthesisPinacol coupling reactionSamuel J. DanishefskyShapiro reactionTakahashi Taxol total synthesisTert-Butyldimethylsilyl chlorideWender Taxol total synthesis
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Nicolaou Taxol total synthesis
The Nicolaou Taxol total synthesis, published by K. C. Nicolaou and his group in 1994 concerns the total synthesis of Taxol. Taxol is an important drug in the treatment of cancer but also expensive because the compound is harvested from a scarce resource, namely the pacific yew. This synthetic route to taxol is one of several; other groups have presented their own solutions, notably the group of Holton with a linear synthesis starting from borneol, the Samuel Danishefsky group starting from the Wieland-Miescher ketone and the Wender group from pinene.
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The Nicolaou Taxol total synth ...... 95 in a series of four papers.
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The Nicolaou Taxol total synth ...... the Wender group from pinene.
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Nicolaou Taxol total synthesis
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