Non-allelic homologous recombination
Non-allelic homologous recombination (NAHR) is a form of homologous recombination that occurs between two lengths of DNA that have high sequence similarity, but are not alleles. It usually occurs between sequences of DNA that have been previously duplicated through evolution, and therefore have low copy repeats (LCRs). These repeat elements typically range from 10–300 kb in length and share 95-97% sequence identity. During meiosis or mitosis, LCRs can misalign and subsequent crossing-over can result in genetic rearrangement. When non-allelic homologous recombination occurs between different LCRs, deletions or further duplications of the DNA can occur. This can give rise to rare genetic disorders, caused by the loss or increased copy number of genes within the deleted or duplicated region.
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1q21.1 copy number variations1q21.1 deletion syndrome22q11.2 duplication syndrome3q29 microdeletion syndrome8p23.1 duplication syndromeC8orf34Contiguous gene syndromeCopy number variationEvolution of snake venomHaploinsufficiencyKoolen–De Vries syndromeLow copy repeatsNAHRNahrNon allelic homologous recombinationNonallelic homologous recombinationOlduvai domainPotocki–Lupski syndromeRisk factors of schizophreniaSegmental duplication on the human Y chromosomeXp11.2 duplication
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Non-allelic homologous recombination
Non-allelic homologous recombination (NAHR) is a form of homologous recombination that occurs between two lengths of DNA that have high sequence similarity, but are not alleles. It usually occurs between sequences of DNA that have been previously duplicated through evolution, and therefore have low copy repeats (LCRs). These repeat elements typically range from 10–300 kb in length and share 95-97% sequence identity. During meiosis or mitosis, LCRs can misalign and subsequent crossing-over can result in genetic rearrangement. When non-allelic homologous recombination occurs between different LCRs, deletions or further duplications of the DNA can occur. This can give rise to rare genetic disorders, caused by the loss or increased copy number of genes within the deleted or duplicated region.
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La ricombinazione omologa non ...... ndrome da microdelezione 3q29.
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Non-allelic homologous recombi ...... r 3q29 microdeletion syndrome.
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La ricombinazione omologa non ...... sono alleli dello stesso gene.
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Non-allelic homologous recombi ...... deleted or duplicated region.
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Non-allelic homologous recombination
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Ricombinazione omologa non allelica
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