Nozaki–Hiyama–Kishi reaction

The Nozaki–Hiyama–Kishi reaction is a nickel/chromium coupling reaction forming an alcohol from the reaction of an aldehyde with an allyl or vinyl halide. In their original 1977 publication, Tamejiro Hiyama and Hitoshi Nozaki reported on a chromium(II) salt solution prepared by reduction of chromic chloride by lithium aluminium hydride to which was added benzaldehyde and allyl chloride: In the same year Yoshito Kishi et al. independently discovered the beneficial effects of nickel in his quest for palytoxin: Palladium acetate was also found to be an effective cocatalyst.

Nozaki–Hiyama–Kishi reaction

The Nozaki–Hiyama–Kishi reaction is a nickel/chromium coupling reaction forming an alcohol from the reaction of an aldehyde with an allyl or vinyl halide. In their original 1977 publication, Tamejiro Hiyama and Hitoshi Nozaki reported on a chromium(II) salt solution prepared by reduction of chromic chloride by lithium aluminium hydride to which was added benzaldehyde and allyl chloride: In the same year Yoshito Kishi et al. independently discovered the beneficial effects of nickel in his quest for palytoxin: Palladium acetate was also found to be an effective cocatalyst.