Nubia (/ˈnjuːbiə/) is a region along the Nile river encompassing the area between the first cataract of the Nile (just south of Aswan in southern Egypt) and the confluence of the Blue and White Niles (in Khartoum in central Sudan), or more strictly, Al Dabbah. It was the seat of one of the earliest civilizations of ancient Africa, the Kerma culture, which lasted from around 2500 BC until its conquest by the New Kingdom of Egypt under Pharaoh Thutmose I around 1500 BC, whose heirs ruled most of Nubia for the next 400 years. Nubia was home to several empires, most prominently the Kingdom of Kush, which conquered Egypt in eighth-century BC during the reign of Piye and ruled the country as its 25th Dynasty (to be replaced a century later by the native Egyptian 26th Dynasty).