Nushagak Bay /ˈnuːʃɪɡæk/ is a large estuary covering over 100 km2 in southwest part of the U.S. state of Alaska. It opens to Bristol Bay, a large body of water in the eastern Bering Sea north of the Alaska Peninsula. It is home to the area's largest city, Dillingham, and the bay hosts one of the world's last great sustainable sockeye salmon fisheries. Nushagak Bay is downstream of the proposed Pebble Mine, whose tailings storage lake would sit at the headwaters of the , one of the Nushagak River's tributaries. Villages on the Nushagak are among the major opponents of the proposal.