ORG-12962
ORG-12962 is a pyridinylpiperazine drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes. It was developed as a potential anti-anxiety drug, but was discontinued from human trials after tests in a public speaking challenge showed that its anti-anxiety effects were accompanied by side effects such as dizziness and a "spacey" feeling, which were attributed to poor selectivity in vivo over the hallucinogenic 5-HT2A receptor.
Wikipage redirect
primaryTopic
ORG-12962
ORG-12962 is a pyridinylpiperazine drug developed by Organon, which acts as a potent and selective agonist for the 5-HT2 receptor family, with highest affinity at 5-HT2C and lowest at 5-HT2B subtypes. It was developed as a potential anti-anxiety drug, but was discontinued from human trials after tests in a public speaking challenge showed that its anti-anxiety effects were accompanied by side effects such as dizziness and a "spacey" feeling, which were attributed to poor selectivity in vivo over the hallucinogenic 5-HT2A receptor.
has abstract
ORG-12962 is a pyridinylpipera ...... allucinogenic 5-HT2A receptor.
@en
CAS number
210821-63-9
ChEMBL
PubChem
Wikipage page ID
30,849,835
page length (characters) of wiki page
Wikipage revision ID
1,000,662,894
Link from a Wikipage to another Wikipage
CAS number
ChEMBL
ChemSpiderID
IUPAC name
IUPHAR ligand
legal status
Uncontrolled
@en
PubChem
SMILES
C2CNCCN2cccc1CF
@en
StdInChIKey
QZYYPQAYSFBKPW-UHFFFAOYSA-N
@en
Verifiedfields
changed
@en
verifiedrevid
462,265,658
wikiPageUsesTemplate
comment
ORG-12962 is a pyridinylpipera ...... allucinogenic 5-HT2A receptor.
@en
label
ORG-12962
@en