State Highway 49 (SH-49) is a 30-mile-long (48 km) state highway in the U.S. state of Oklahoma. It runs from SH-54 in Kiowa County to Interstate 44 (I-44) near Lawton. Part of the highway runs through the Wichita Mountains Wildlife Refuge; this portion of SH-49 carries no signage identifying it as such. It has no lettered spur routes. SH-49 was established in 1939. Originally it turned south in the refuge to serve Cache; its present-day routing was established in 1973.