The Old Wire Road is a historic road in Missouri and Arkansas. Several local roads are still known by this name. It followed an old Native American route, the Great Osage Trail across the Ozarks and became a road along a telegraph line from St. Louis, Missouri, to Fort Smith, Arkansas. This route was also used by the Butterfield Overland Mail. It was known as the "Wire Road" while the telegraph line was up, but when the line was later removed, it simply became known as the "Old Wire Road". In St. Louis, where the road begins at Jefferson Barracks, it is called Telegraph Road. From St. Louis to Springfield, Missouri, it became designated Route 14 (which, in turn, later became U.S. Route 66 and still later Interstate 44).