The Orange County Regiment was authorized on September 9, 1775 by the Province of North Carolina Congress. On April 22, 1776, the unit was split into the Northern Orange County Regiment and the Southern Orange County Regiment, which retained most of the original men. Both regiments were subordinated to the Hillsborough District Brigade of militia on May 4, 1776. When the North Orange County Regiment was renamed the Caswell County Regiment on May 9, 1777, the Southern Orange County Regiment name reverted to the Orange County Regiment. The regiment was engaged in battles and skirmishes against the British during the American Revolution in North Carolina, South Carolina and Georgia between 1776 and 1782. It was active until the end of the war.