PDX1
PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1. The gene was originally identified in the clawed frog Xenopus laevis and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes. Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals. Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx
Development of the digestive systemEpigenetics of diabetes Type 2Examples of in vitro transdifferentiation by lineage-instructive approachFat sand ratGinkgotoxinHomeoboxIPF1Induced stem cellsInsulinInsulin promoter factor-1Insulin promoter factor 1Ipf1List of OMIM disorder codesList of human protein-coding genes 3List of intestinal epithelial differentiation genesMAFA (gene)MODY 4Maturity onset diabetes of the youngPDXPDX1 (gene)PancreasPancreatic and duodenal homeobox proteinPancreatic progenitor cellParaHoxPdx1Pdx (gene family)TSBP1Transcription factorTransdifferentiationXlox
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PDX1
PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1. The gene was originally identified in the clawed frog Xenopus laevis and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes. Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals. Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx
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PDX1 (pancreatic and duodenal ...... two Pdx genes, Pdx1 and Pdx2.
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PDX1 (pancreatic and duodenal ...... own to have two Pdx genes, Pdx
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PDX1
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